Lattm1.1Mal
Targeted Allele Detail
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| Symbol: |
Lattm1.1Mal |
| Name: |
linker for activation of T cells; targeted mutation 1.1, Bernard Malissen |
| MGI ID: |
MGI:2182312 |
| Synonyms: |
LatY136F, LATY136F, LatY6F |
| Gene: |
Lat Location: Chr7:125962996-125968742 bp, - strand Genetic Position: Chr7, 69.01 cM
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| Alliance: |
Lattm1.1Mal page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:77098
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| Parent Cell Line: |
CK35 (ES Cell)
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| Strain of Origin: |
129S2/SvPas
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| Allele Type: |
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Targeted |
| Mutation: |
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Nucleotide substitutions
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Mutation details: Tyrosine codon 136 in exon 7 was changed to a phenylalanine (p.Y136F) through an A-to-T mutation. In addition to the intended mutation, a new Bgl II restriction enzyme cleavage site was introduced in the intron 3' of exon 7 to accommodate a loxP site flanked neomycin resistance gene. Founder mice were bred to deleter mice to eliminate the floxed neo cassette leaving a single loxP site in intron 7. Western blot analysis of CD4-positive T cells verified the presence of protein product in mutant animals.
(J:77098)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Lat Mutation: |
9 strains or lines available
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| Original: |
J:77098 Aguado E, et al., Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science. 2002 Jun 14;296(5575):2036-40 |
| All: |
21 reference(s) |
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Analysis Tools
