Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Cyp1a1tm1Dwn
Name:	cytochrome P450, family 1, subfamily a, polypeptide 1; targeted mutation 1, Daniel W Nebert
MGI ID:	MGI:2182305
Gene:	Cyp1a1  Location: Chr9:57595211-57611107 bp, + strand  Genetic Position: Chr9, 31.34 cM
Alliance:	Cyp1a1tm1Dwn page

Germline Transmission:	Earliest citation of germline transmission: J:59398
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A HPRT minigene, flanked by loxP sites, was inserted into intron 1. An additional loxP site was inserted in the 3' untranslated region. Mice heterozygous for this allele were used to generate Cyp1a1tm1.1Dwn. (J:59398)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cyp1a1 Mutation:	38 strains or lines available

Original:	J:59398 Dalton TP, et al., Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery. Biochem Biophys Res Commun. 2000 Jan 7;267(1):184-9
All:	4 reference(s)