Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lhcgrtm1Hht
Name:	luteinizing hormone/choriogonadotropin receptor; targeted mutation 1, Ilpo Huhtaniemi
MGI ID:	MGI:2181999
Synonyms:	LHR -, LuRKO
Gene:	Lhcgr  Location: Chr17:89023909-89099418 bp, - strand  Genetic Position: Chr17, 58.35 cM
Alliance:	Lhcgrtm1Hht page

Germline Transmission:	Earliest citation of germline transmission: J:66818
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 11, which encodes the transmembrane and cytoplasmic receptor domains, was replaced with a neomycin selection gene by homologous recombination. RT-PCR analysis demonstrated that no full length transcript was made in homozygous mice. Radioimmunoassays confirmed that no functional protein was present in homozygous mice. (J:66818)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	27 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lhcgr Mutation:	43 strains or lines available

Original:	J:66818 Zhang FP, et al., Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice. Mol Endocrinol. 2001 Jan;15(1):172-83
All:	18 reference(s)