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Tg(Ttr-Hamp)TH5Svl
Transgene Detail
Summary
Symbol: Tg(Ttr-Hamp)TH5Svl
Name: transgene insertion TH5, Sophie Vaulont
MGI ID: MGI:2181882
Synonyms: TH5, Thep27, Thepc27
Transgene: Tg(Ttr-Hamp)TH5Svl  Location: unknown  
Alliance: Tg(Ttr-Hamp)TH5Svl page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ttr-Hamp)TH5Svl expresses 1 gene
 
Mutation detailsThe full-length mouse cDNA was used as a transgene. The transgene was fused to mouse transthyretin regulatory sequences to drive liver-specific expression. (J:75776)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Founder TH5 is representative of a group of transgenic lines (TH5, TH35, and TH61) that survive to adulthood but exhibit small size, apathy, poor coat, and crumpled skin. Founder TH61 manifests the phenotype later in life, after approximately 2-3 weeks. All trangenic lines contain at least 2 copies of the transgene.
References
Original:  J:75776 Nicolas G, et al., Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4596-601
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/28/2026
MGI 6.24
The Jackson Laboratory