Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rom1tm1Mci
Name:	rod outer segment membrane protein 1; targeted mutation 1, Roderick R McInnes
MGI ID:	MGI:2181662
Synonyms:	Rom1-
Gene:	Rom1  Location: Chr19:8904755-8906720 bp, - strand  Genetic Position: Chr19, 6.03 cM
Alliance:	Rom1tm1Mci page

Germline Transmission:	Earliest citation of germline transmission: J:61888
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced exon 1 and a 5' portion of exon 2. Western blot analysis of crude retinal extracts showed an absence of encoded protein in homozygous mutant mice. (J:61888)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rom1 Mutation:	10 strains or lines available

Original:	J:61888 Clarke G, et al., Rom-1 is required for rod photoreceptor viability and the regulation of disk morphogenesis. Nat Genet. 2000 May;25(1):67-73
All:	7 reference(s)