Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Otogtm1Prs
Name:	otogelin; targeted mutation 1, Marie-Christine Simmler
MGI ID:	MGI:2181633
Synonyms:	Otog-
Gene:	Otog  Location: Chr7:45890411-45960858 bp, + strand  Genetic Position: Chr7, 29.66 cM, cytoband B4-C
Alliance:	Otogtm1Prs page

Germline Transmission:	Earliest citation of germline transmission: J:60193
Parent Cell Line:	CK35 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The majority of exon 1 and all of exons 2 and 3 were replaced with a NLS-lacZ and neo cassette inserted immediately downstream of the endogenous start codon. RT-PCR analysis of inner ear tissue showed an absence of transcript in homozygous mutant mice. Immunohistolabelling was reported to additionally confirm inactivation (data not shown). (J:60193)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Otog Mutation:	149 strains or lines available

Original:	J:60193 Simmler MC, et al., Targeted disruption of otog results in deafness and severe imbalance [see comments]. Nat Genet. 2000 Feb;24(2):139-43
All:	4 reference(s)