Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Creb1tm3Gsc
Name:	cAMP responsive element binding protein 1; targeted mutation 3, Gunther Schutz
MGI ID:	MGI:2181395
Synonyms:	Creb1loxP, CREBfl, Creblox
Gene:	Creb1  Location: Chr1:64571963-64643707 bp, + strand  Genetic Position: Chr1, 32.74 cM, cytoband C1/C5
Alliance:	Creb1tm3Gsc page

Germline Transmission:	Earliest citation of germline transmission: J:76211
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A single loxP site was inserted 5' to exon 10 and a loxP flanked neomycin and thymidine kinase cassette was inserted 3' to exon 10. Transient transfection of Cre recombinase in ES cells resulted in the deletion of the neomycin and thymidine kinase cassette, leaving single loxP sites flanking exon 10 in the final allele. (J:76211)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Creb1 Mutation:	59 strains or lines available

Original:	J:76211 Mantamadiotis T, et al., Disruption of CREB function in brain leads to neurodegeneration. Nat Genet. 2002 May;31(1):47-54
All:	36 reference(s)