Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cry1tm1Jhjh
Name:	cryptochrome circadian regulator 1; targeted mutation 1, Jan J H Hoeijmakers
MGI ID:	MGI:2181205
Synonyms:	cry1-, mCry1-
Gene:	Cry1  Location: Chr10:84967564-85020918 bp, - strand  Genetic Position: Chr10, 41.63 cM, cytoband C
Alliance:	Cry1tm1Jhjh page

Germline Transmission:	Earliest citation of germline transmission: J:54241
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced coding sequence corresponding to base pairs 730 through 1479 in the cDNA sequence. RT-PCR followed by Southern blot analysis, using the complete cDNA as a probe, confirmed a lack of transcript in homozygous mutant mice. (J:54241)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cry1 Mutation:	35 strains or lines available

Original:	J:54241 van der Horst GT, et al., Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms [see comments]. Nature. 1999 Apr 15;398(6728):627-30
All:	63 reference(s)