Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Sim2tm1Fan
Name:	single-minded family bHLH transcription factor 2; targeted mutation 1, Chen-Ming Fan
MGI ID:	MGI:2180881
Gene:	Sim2  Location: Chr16:93885963-93927891 bp, + strand  Genetic Position: Chr16, 55.05 cM, cytoband C3.3-C4
Alliance:	Sim2tm1Fan page

Germline Transmission:	Earliest citation of germline transmission: J:76787
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 422 bp of the 5' untranslated region and the first 144 bp of the gene coding region were replaced with a PGK-neo cassette via homologous recombination. The gene targeting event results in deletion of the first 48 amino acids of the basic helix-loop-helix domain. Gene expression is absent in kidneys from homozygous mutant animals as determined by in situ hybridization. (J:76787)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sim2 Mutation:	22 strains or lines available

Original:	J:76787 Goshu E, et al., Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants. Mol Cell Biol. 2002 Jun;22(12):4147-57
All:	5 reference(s)