Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cd7tm1Bfh
Name:	CD7 antigen; targeted mutation 1, Barton F Haynes
MGI ID:	MGI:2180804
Synonyms:	CD7-
Gene:	Cd7  Location: Chr11:120927573-120930244 bp, - strand  Genetic Position: Chr11, 84.85 cM
Alliance:	Cd7tm1Bfh page

Germline Transmission:	Earliest citation of germline transmission: J:48758
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 was disrupted by the introduction of a stop codon upstream of sequence encoding the transmembrane domain. A PGK-neo cassette was inserted just downstream of the introduced stop codon. Northern blot analysis of thymocytes and splenocytes showed a lack of protein expression in homozygous mutant mice. These results were confirmed by RT-PCR analysis. (J:48758)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd7 Mutation:	13 strains or lines available

Original:	J:48758 Lee DM, et al., Immunologic characterization of CD7-deficient mice. J Immunol. 1998 Jun 15;160(12):5749-56
All:	5 reference(s)