Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Ccnd2tm1Wbg
Name:	cyclin D2; targeted mutation 1, Robert A Weinberg
MGI ID:	MGI:2180642
Synonyms:	CD2-, cyclin D2-, D2-
Gene:	Ccnd2  Location: Chr6:127102125-127129156 bp, - strand  Genetic Position: Chr6, 61.92 cM
Alliance:	Ccnd2tm1Wbg page

Germline Transmission:	Earliest citation of germline transmission: J:37092
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The insertion of a neomycin selection cassette deleted exons 1 and 2. Protein was not detected in lysates from homozygous mutant embryos by Western blot analysis. (J:37092) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	41 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

List all tumor models in MMHCdb carrying Ccnd2tm1Wbg

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccnd2 Mutation:	24 strains or lines available

Original:	J:37092 Sicinski P, et al., Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature. 1996 Dec 5;384(6608):470-4
All:	56 reference(s)