Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cbltm1Ddlb
Name:	Casitas B-lineage lymphoma; targeted mutation 1, David D L Bowtell
MGI ID:	MGI:2180578
Synonyms:	c-Cbl-
Gene:	Cbl  Location: Chr9:44054273-44145346 bp, - strand  Genetic Position: Chr9, 24.72 cM
Alliance:	Cbltm1Ddlb page

Germline Transmission:	Earliest citation of germline transmission: J:76895
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The insertion of a PGK-neo cassette disrupted the exon encoding the phosphotyrosine binding (PTB) domain. Western blot analysis confirmed an absence of normal protein product in homozygous mutant mice. The presence of a truncated protein was noted and determined to be the result of an in-frame splicing event in which the targeted exon was deleted, thus all peptides produced from targeted alleles lacked the conserved residues within the PTB domain. (J:76895)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Cbl Mutation:	57 strains or lines available

Original:	J:76895 Murphy MA, et al., Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice. Mol Cell Biol. 1998 Aug;18(8):4872-82
All:	18 reference(s)