Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Selplgtm1Rpmc
Name:	selectin, platelet (p-selectin) ligand; targeted mutation 1, Rodger P McEver
MGI ID:	MGI:2180375
Synonyms:	PSGL-1-, PSGL-1 KO, Selpl-
Gene:	Selplg  Location: Chr5:113956597-113970705 bp, - strand  Genetic Position: Chr5, 55.59 cM
Alliance:	Selplgtm1Rpmc page

Germline Transmission:	Earliest citation of germline transmission: J:75829
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced the 5' portion of exon 2, which includes the translation initiation start site, via homologous recombination. Flow cytometry was used to confirm the absence of gene expression in leukocytes of homozygous mutant animals. (J:75829, J:95268)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Selplg Mutation:	49 strains or lines available

Original:	J:75829 Xia L, et al., P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow. J Clin Invest. 2002 Apr;109(7):939-50
All:	25 reference(s)