Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol: Bmal1tm1Bra Name: basic helix-loop-helix ARNT like 1; targeted mutation 1, Christopher A Bradfield MGI ID: MGI:2180361 Synonyms: bmal1-, Bmal1-KO, mMop3-, Mop3- Gene: Bmal1  Location: Chr7:112806672-112913333 bp, + strand  Genetic Position: Chr7, 59.17 cM, cytoband F2-F3 Alliance: Bmal1tm1Bra page

Joint abnormalities with ectopic ossification in Bmal1tm1Bra/Bmal1tm1Bra mice Show the 6 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:66502
Parent Cell Line:	GS1 (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A portion of exon 4 containing the helix-loop-helix coding domain and all of exon 5 were replaced by a neomycin selection cassette. A larger transcript, resulting from a cryptic splice site between exon 3 and the neomycin resistance gene, was detected by Northern blot analysis. The polypeptide truncates 15 residues after this splice site, prior to the functional domains encoded by exon 4 in the wild-type locus. (J:66502)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	9 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	37 anatomical structure(s)

List all tumor models in MMHCdb carrying Bmal1tm1Bra

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bmal1 Mutation:	137 strains or lines available

Original:	J:66502 Bunger MK, et al., Mop3 is an essential component of the master circadian pacemaker in mammals. Cell. 2000 Dec 22;103(7):1009-17
All:	149 reference(s)