Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Phox2atm1Jbr
Name:	paired-like homeobox 2a; targeted mutation 1, Jean-Francois Brunet
MGI ID:	MGI:2180328
Synonyms:	Phox2a-
Gene:	Phox2a  Location: Chr7:101467520-101471933 bp, + strand  Genetic Position: Chr7, 54.66 cM
Alliance:	Phox2atm1Jbr page

Germline Transmission:	Earliest citation of germline transmission: J:39084
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin cassette was used to delete a portion of exon 2 and all of exon 3, eliminating the sequences encoding the homeodomain and all downstream sequence. The truncated message was believed to be unstable due to the absence of a signal in Northern blot analysis. (J:39084)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Phox2a Mutation:	10 strains or lines available

Original:	J:39084 Morin X, et al., Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a. Neuron. 1997 Mar;18(3):411-23
All:	4 reference(s)