Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fertm1Pag
Name:	FER tyrosine kinase; targeted mutation 1, Peter A Greer
MGI ID:	MGI:2180299
Synonyms:	ferD743R, ferDR
Gene:	Fer  Location: Chr17:64170057-64446491 bp, + strand  Genetic Position: Chr17, 33.06 cM
Alliance:	Fertm1Pag page

Germline Transmission:	Earliest citation of germline transmission: J:67350
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Not Specified) Mutations:    Insertion, Nucleotide substitutions   Mutation details: An aspartate to arginine mutation at position 743 (D743R) was introduced into exon 19 via homologous recombination in conjunction with a neo resistance cassette downstream of exon 20. The mutation is designed to inactivate the kinase domain by destabilizing the catalytic loop. Western blot analysis of homozygous mutant animals detected protein expression in testis but greatly reduced protein expression in liver. Kinase assays demonstrated complete absence of kinase activity in both testis and liver extracts from homozygous mutants. (J:67350)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fer Mutation:	36 strains or lines available

Original:	J:67350 Craig AW, et al., Mice devoid of fer protein-tyrosine kinase activity are viable and fertile but display reduced cortactin phosphorylation. Mol Cell Biol. 2001 Jan;21(2):603-13
All:	11 reference(s)