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Cacna1atm1Fcr
Targeted Allele Detail
Summary
Symbol: Cacna1atm1Fcr
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; targeted mutation 1, Frederick Cancer Research and Development Center
MGI ID: MGI:2180190
Synonyms: Cacna1aFcrtm1
Gene: Cacna1a  Location: Chr8:85065268-85366875 bp, + strand  Genetic Position: Chr8, 40.95 cM
Alliance: Cacna1atm1Fcr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76459
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 14-17 of this gene, which encode the pore-lining domain and 3 transmembrane domains of domain II, were replaced with a neo resistance cassette via homologous recombination. Western blot of cerebellar and forebrain extracts from homozygous mutant mice verified the absence of protein product. (J:76459)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacna1a Mutation:  115 strains or lines available
References
Original:  J:76459 Fletcher CF, et al., Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity. FASEB J. 2001 May;15(7):1288-90
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory