Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cacna1btm1Ksw
Name:	calcium channel, voltage-dependent, N type, alpha 1B subunit; targeted mutation 1, Kohei Sawada
MGI ID:	MGI:2180187
Synonyms:	alpha-, alpha1B-, Cav2.2-
Gene:	Cacna1b  Location: Chr2:24493899-24653164 bp, - strand  Genetic Position: Chr2, 16.58 cM, cytoband A2
Alliance:	Cacna1btm1Ksw page

Germline Transmission:	Earliest citation of germline transmission: J:76458
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The exon encoding the central portion of the cytoplasmic repeat II-III linker was disrupted by insertion of a PGK-neo cassette via homologous recombination. RT-PCR analysis verified the presence of mutant transcripts in brain of homozygous mutant animals. (J:76458)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacna1b Mutation:	103 strains or lines available

Original:	J:76458 Ino M, et al., Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5323-8
All:	24 reference(s)