Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tle5tm1Grid
Name:	TLE family member 5, transcriptional modulator; targeted mutation 1, Tom Gridley
MGI ID:	MGI:2180116
Synonyms:	Aes-, Grg5-, Grgdelta1
Gene:	Tle5  Location: Chr10:81395322-81402196 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance:	Tle5tm1Grid page

Germline Transmission:	Earliest citation of germline transmission: J:29516
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced exon 2 and also introduces both termination and polyadenylation signals into the open reading frame. The authors noted that if the aforementioned signals were not recognized, the splicing of exons 1 and 3 would result in frameshift mutation. Western analysis of lysates isolated from the brains and spleens of homozygous mutant mice showed an absence of protein expression. (J:29516)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tle5 Mutation:	19 strains or lines available

Original:	J:29516 Mallo M, et al., Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex. Dev Dyn. 1995 Nov;204(3):338-47
All:	5 reference(s)