Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nefmtm1Jpj
Name:	neurofilament, medium polypeptide; targeted mutation 1, Jean-Pierre Julien
MGI ID:	MGI:2180106
Synonyms:	NF-M-
Gene:	Nefm  Location: Chr14:68356994-68362453 bp, - strand  Genetic Position: Chr14, 35.46 cM
Alliance:	Nefmtm1Jpj page

Germline Transmission:	Earliest citation of germline transmission: J:56931
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of exon 1 with a neomycin resistance cassette via homologous recombination. Absence of gene expression was verified in Northern blots of brain from homozygous mutant animals. (J:56931)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nefm Mutation:	28 strains or lines available

Original:	J:56931 Jacomy H, et al., Disruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunits. J Neurochem. 1999 Sep;73(3):972-84
All:	9 reference(s)