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Ltbp3tm1Bdvc
Targeted Allele Detail
Summary
Symbol: Ltbp3tm1Bdvc
Name: latent transforming growth factor beta binding protein 3; targeted mutation 1, Branka Dabovic
MGI ID: MGI:2180017
Synonyms: Ltbp-3-null
Gene: Ltbp3  Location: Chr19:5790932-5808560 bp, + strand  Genetic Position: Chr19, 4.34 cM, cytoband B
Alliance: Ltbp3tm1Bdvc page
Skeletal abnormalities in Ltbp3tm1Bdvc/Ltbp3tm1Bdvc mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76213
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsTwo exons of this gene spanning nucleotides 278-807 were replaced with a neo resistance cassette, causing a frameshift in the ORF resulting in premature translation termination and deletion of the first EGF-like repeat, the pro-gly-rich region, and the beginning of the first 8-cys domain. Northern blot analysis of lung from homozygous mutant animals using a probe corresponding to the deleted exons failed to detect transcripts. (J:76213)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 24 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ltbp3 Mutation:  58 strains or lines available
References
Original:  J:76213 Dabovic B, et al., Bone abnormalities in latent TGF-[beta] binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-[beta] bioavailability. J Cell Biol. 2002 Jan 21;156(2):227-32
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory