Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Achetm1Loc
Name:	acetylcholinesterase; targeted mutation 1, Oksana Lockridge
MGI ID:	MGI:2179948
Synonyms:	AChE-, AChE ko
Gene:	Ache  Location: Chr5:137286516-137292728 bp, + strand  Genetic Position: Chr5, 76.32 cM
Alliance:	Achetm1Loc page

Germline Transmission:	Earliest citation of germline transmission: J:56242
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 5 kb genomic fragment containing exons 2-5 was replaced by a neomycin resistance gene cassette. Enzymatic activity assays on blood serum derived from homozygous mice confirmed that no functional protein was made from this allele. (J:56242)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ache Mutation:	30 strains or lines available

Original:	J:56242 Xie W, et al., Knockout of one acetylcholinesterase allele in the mouse. Chem Biol Interact. 1999 May 14;119-120:289-99
All:	23 reference(s)