Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Vamp2tm1Sud
Name:	vesicle-associated membrane protein 2; targeted mutation 1, Thomas C Sudhof
MGI ID:	MGI:2179745
Synonyms:	syb 2 -, synaptobrevin/VAMP2-
Gene:	Vamp2  Location: Chr11:68979354-68983207 bp, + strand  Genetic Position: Chr11, 42.36 cM
Alliance:	Vamp2tm1Sud page

Germline Transmission:	Earliest citation of germline transmission: J:72714
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A loxP-flanked neomycin resistance cassette was inserted 104 bp upstream of the initiation codon. Western blot analysis on brain extracts derived from homozygous mice confirmed that no detectable protein is produced from this allele. (J:72714)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vamp2 Mutation:	18 strains or lines available

Original:	J:72714 Schoch S, et al., SNARE function analyzed in synaptobrevin/VAMP knockout mice. Science. 2001 Nov 2;294(5544):1117-22
All:	27 reference(s)