Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cacna1etm1Ttan
Name:	calcium channel, voltage-dependent, R type, alpha 1E subunit; targeted mutation 1, Tsutomu Tanabe
MGI ID:	MGI:2179732
Synonyms:	alpha(1E)-, alpha1E-, Cav2.3-
Gene:	Cacna1e  Location: Chr1:154266477-154760247 bp, - strand  Genetic Position: Chr1, 66.14 cM
Alliance:	Cacna1etm1Ttan page

Germline Transmission:	Earliest citation of germline transmission: J:62285
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: Exon 1 of this gene was disrupted by insertion of a lacZneo-derived cassette via homologous recombination. RT-PCR and Northern blot analysis of brain RNA and Western blot analysis of brain membrane proteins from homozygous mutant animals verified the absence of gene expression. (J:62285)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cacna1e Mutation:	102 strains or lines available

Original:	J:62285 Saegusa H, et al., Altered pain responses in mice lacking alpha 1E subunit of the voltage-dependent Ca2+ channel. Proc Natl Acad Sci U S A. 2000 May 23;97(11):6132-7
All:	12 reference(s)