Slc6a6tm1Dhau
Targeted Allele Detail
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Symbol: |
Slc6a6tm1Dhau |
Name: |
solute carrier family 6 (neurotransmitter transporter, taurine), member 6; targeted mutation 1, Dieter Haussinger |
MGI ID: |
MGI:2179132 |
Synonyms: |
taut- |
Gene: |
Slc6a6 Location: Chr6:91661031-91736044 bp, + strand Genetic Position: Chr6, 40.73 cM
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Alliance: |
Slc6a6tm1Dhau page
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Germline Transmission: |
Earliest citation of germline transmission:
J:74276
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 1 of this gene was replaced with a neomycin resistance gene via homologous recombination, resulting in a truncated protein deleted for transmembrane domains 1-2 as well as a large portion of the extracellular region. Transcripts including exon 1 were not expressed in kidney and liver of homozygous mutant animals as assayed by Northern blot.
(J:74276)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Slc6a6 Mutation: |
319 strains or lines available
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Original: |
J:74276 Heller-Stilb B, et al., Disruption of the taurine transporter gene (taut) leads to retinal degeneration in mice. FASEB J. 2002 Feb;16(2):231-3 |
All: |
14 reference(s) |
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