Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adra2atm1Bkk
Name:	adrenergic receptor, alpha 2a; targeted mutation 1, Brian K Kobilka
MGI ID:	MGI:2179108
Synonyms:	alpha2A-, alpha2A-AR-, alpha2A-ARKO, alpha2A-KO
Gene:	Adra2a  Location: Chr19:54033690-54037413 bp, + strand  Genetic Position: Chr19, 49.04 cM
Alliance:	Adra2atm1Bkk page

Germline Transmission:	Earliest citation of germline transmission: J:76317
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin cassette inserted into the gene by homologous recombination resulted in a premature stop codon within the third transmembrane domain. Confirmation of the targeting event was demonstrated through Southern analysis. (J:76317)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adra2a Mutation:	23 strains or lines available

Original:	J:76317 Altman JD, et al., Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice. Mol Pharmacol. 1999 Jul;56(1):154-61
All:	57 reference(s)