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Gene Expression Data
Assay Details
Assay
Reference: J:73071 Long F, et al., Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development. 2001 Dec;128(24):5099-108
Assay type: RNA in situ
MGI Accession ID: MGI:2178829
Gene symbol: Gli1
Gene name: GLI-Kruppel family member GLI1
Probe: Gli1 probe2
Probe preparation: Antisense labelled with S35 RNA
Results
Specimen 3 WT: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: tibia cartilage condensation Present 3_Gli1 E14.5 WT Expression was present in proliferating chondrocytes.
Specimen 3 Cre15;Smon/c: embryonic day 14.5; Smotm1Amc/Smotm2Amc, Tg(Col2a1-cre)15Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: tibia cartilage condensation Present Single cells 3_Gli1 E14.5 Cre15;Smon/c Expression was detected in a few chondrocytes.
TS22: lower leg rest of mesenchyme Present Regionally restricted 3_Gli1 E14.5 Cre15;Smon/c Expression was detected in the perichondrium.
Specimen 3 Cre10;Smon/c: embryonic day 14.5; Smotm1Amc/Smotm2Amc, Tg(Col2a1-cre)10Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: tibia cartilage condensation Absent 3_Gli1 E14.5 Cre10;Smon/c The mutant completely lacked expression in immature proliferating chondrocytes.
TS22: lower leg rest of mesenchyme Present Regionally restricted 3_Gli1 E14.5 Cre10;Smon/c Expression was detected in the perichondrium.
Specimen not shown: embryonic day 14.5; Smotm1Amc/Smotm2Amc, Tg(Col2a1-cre)3Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: tibia cartilage condensation Present Single cells Expression was detected in a few chondrocytes.
TS22: lower leg rest of mesenchyme Present Regionally restricted Expression was detected in the perichondrium.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory