Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nfibtm1Hsch
Name:	nuclear factor I/B; targeted mutation 1, Heinrich Schrewe
MGI ID:	MGI:2178748
Synonyms:	NfibE2-lacZ
Gene:	Nfib  Location: Chr4:82208410-82424988 bp, - strand  Genetic Position: Chr4, 38.4 cM, cytoband C4-C6
Alliance:	Nfibtm1Hsch page

Germline Transmission:	Earliest citation of germline transmission: J:75698
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A lacZ reporter gene was inserted in frame into the DNA binding domain of exon 2. A Nfib-lacZ fusion mRNA is generated containing only the first 11 codons of the Nfib gene. (J:75698)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfib Mutation:	91 strains or lines available

Original:	J:75698 Grunder A, et al., Nuclear factor I-B (Nfib) deficient mice have severe lung hypoplasia. Mech Dev. 2002 Mar;112(1-2):69-77
All:	1 reference(s)