Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hellstm1Kmu
Name:	helicase, lymphoid specific; targeted mutation 1, Kathrin Muegge
MGI ID:	MGI:2178586
Synonyms:	Lsh -
Gene:	Hells  Location: Chr19:38919359-38959495 bp, + strand  Genetic Position: Chr19, 33.57 cM, cytoband C3-D1
Alliance:	Hellstm1Kmu page

Germline Transmission:	Earliest citation of germline transmission: J:76112
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 6 and 7, containing a helicase domain (ATPase), and a DExH box, were relaced with a PGK-neo cassette. Successful targeting was confirmed by Southern analysis and PCR. Western analysis failed to detect protein from embryonic liver extracts in homozygous mutant animals. (J:76112)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	41 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hells Mutation:	58 strains or lines available

Original:	J:76112 Geiman TM, et al., Lsh, a SNF2 family member, is required for normal murine development. Biochim Biophys Acta. 2001 May 3;1526(2):211-20
All:	12 reference(s)