Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adarb1tm1Phs
Name:	adenosine deaminase, RNA-specific, B1; targeted mutation 1, Peter H Seeburg
MGI ID:	MGI:2178079
Synonyms:	ADAR2 -
Gene:	Adarb1  Location: Chr10:77126560-77254104 bp, - strand  Genetic Position: Chr10, 39.72 cM, cytoband C
Alliance:	Adarb1tm1Phs page

Germline Transmission:	Earliest citation of germline transmission: J:63273
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin resistance gene replaced most of exon 4, which encodes domains essential for protein function. RNase protection assays demonstrated that a mutant transcript was produced from this allele at low levels that may express a functionally inactive protein with intact RNA binding domains. (J:63273)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

5 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Adarb1 Mutation:	35 strains or lines available

Original:	J:63273 Higuchi M, et al., Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Nature. 2000 Jul 6;406(6791):78-81
All:	18 reference(s)