Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Krt8tm1Rgo
Name:	keratin 8; targeted mutation 1, Robert G Oshima
MGI ID:	MGI:2178042
Synonyms:	K8-, mK8 -
Gene:	Krt8  Location: Chr15:101905146-101912777 bp, - strand  Genetic Position: Chr15, 57.2 cM
Alliance:	Krt8tm1Rgo page

Germline Transmission:	Earliest citation of germline transmission: J:12899
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a DNA segment containing most of the first exon including the translation initiation codon. Northern blot analysis on RNA isolated from gut, liver, kidney and spleen demonstrated that an aberrant transcript was made in gut, but no transcript was detectable elsewhere. Immunohistochemistry on sections of intestine of homozygous mice confirmed that no detectable protein was expressed from this allele. (J:12899)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

List all tumor models in MMHCdb carrying Krt8tm1Rgo

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Krt8 Mutation:	34 strains or lines available

Original:	J:12899 Baribault H, et al., Mid-gestational lethality in mice lacking keratin 8. Genes Dev. 1993 Jul;7(7A):1191-202
All:	34 reference(s)