Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gata6tm1Msp
Name:	GATA binding protein 6; targeted mutation 1, Michael S Parmacek
MGI ID:	MGI:2177785
Synonyms:	Gata6-
Gene:	Gata6  Location: Chr18:11052510-11085636 bp, + strand  Genetic Position: Chr18, 5.63 cM
Alliance:	Gata6tm1Msp page

Germline Transmission:	Earliest citation of germline transmission: J:51304
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exons 4 and 5, which encode the zinc finger domains of the encoded protein. In situ hybridization experiments on homozygous embryos demonstrated that no detectable transcript was produced from this allele. (J:51304)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata6 Mutation:	32 strains or lines available

Original:	J:51304 Morrisey EE, et al., GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo. Genes Dev. 1998 Nov 15;12(22):3579-90
All:	6 reference(s)