Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gad2tm1Oba
Name:	glutamic acid decarboxylase 2; targeted mutation 1, Kunihiko Obata
MGI ID:	MGI:2177567
Synonyms:	GAD65 -
Gene:	Gad2  Location: Chr2:22512262-22583889 bp, + strand  Genetic Position: Chr2, 15.15 cM, cytoband A-B
Alliance:	Gad2tm1Oba page

Germline Transmission:	Earliest citation of germline transmission: J:37576
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into exon 3 of the gene. Western blot analysis on brain extracts from homozygous mice confirmed that no detectable protein is expressed from this allele. (J:37576)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gad2 Mutation:	60 strains or lines available

Original:	J:37576 Asada H, et al., Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures. Biochem Biophys Res Commun. 1996 Dec 24;229(3):891-5
All:	17 reference(s)