Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Erbb2tm2Cbm
Name:	erb-b2 receptor tyrosine kinase 2; targeted mutation 2, Carmen Birchmeier
MGI ID:	MGI:2177255
Synonyms:	erbB2flox
Gene:	Erbb2  Location: Chr11:98303310-98328542 bp, + strand  Genetic Position: Chr11, 61.75 cM, cytoband D
Alliance:	Erbb2tm2Cbm page

Germline Transmission:	Earliest citation of germline transmission: J:75421
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: LoxP sites were inserted into intronic sequences flanking three exons. An adjacent loxP flanked neomycin selection cassette was removed in ES cells by transient Cre recombinase transfection prior to the production of chimeric mice. (J:75421)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erbb2 Mutation:	59 strains or lines available

Original:	J:75421 Garratt AN, et al., A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool. J Cell Biol. 2000 Mar 6;148(5):1035-46
All:	12 reference(s)