Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Brca2tm1Brd
Name:	breast cancer 2, early onset; targeted mutation 1, Allan Bradley
MGI ID:	MGI:2177233
Synonyms:	Brca2Brdm1, Brca2KO, Brca2tmBrd1
Gene:	Brca2  Location: Chr5:150446095-150493794 bp, + strand  Genetic Position: Chr5, 89.52 cM
Alliance:	Brca2tm1Brd page

Germline Transmission:	Earliest citation of germline transmission: J:39764
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-hprt minigene cassette replaced 2.8 kb of coding sequences corresponding to amino acids 626-1437 of the encoded protein. (J:39764)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

List all tumor models in MMHCdb carrying Brca2tm1Brd

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Brca2 Mutation:	132 strains or lines available

Original:	J:39764 Sharan SK, et al., Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 [see comments]. Nature. 1997 Apr 24;386(6627):804-10
All:	7 reference(s)