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Efnb2tm2And
Targeted Allele Detail
Summary
Symbol: Efnb2tm2And
Name: ephrin B2; targeted mutation 2, David J Anderson
MGI ID: MGI:2176538
Synonyms: Efnb2flox, EphrinB2LoxP
Gene: Efnb2  Location: Chr8:8667434-8711242 bp, - strand  Genetic Position: Chr8, 3.42 cM
Alliance: Efnb2tm2And page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74909
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted 45 bp upstream in the 5' UTR and a floxed PGKneo cassette was inserted downstream of the first exon. The floxed PGKneo cassette was removed by transient Cre expression in the ES cells which resulted in a floxed intact exon I. (J:74909)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 28 assay results
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Efnb2 Mutation:  28 strains or lines available
References
Original:  J:74909 Gerety SS, et al., Cardiovascular ephrinB2 function is essential for embryonic angiogenesis. Development. 2002 Mar;129(6):1397-410
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory