Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mpotm1Mae
Name:	myeloperoxidase; targeted mutation 1, Nobuyo Maeda
MGI ID:	MGI:2176344
Synonyms:	Mpo-
Gene:	Mpo  Location: Chr11:87684610-87695238 bp, + strand  Genetic Position: Chr11, 52.22 cM, cytoband C
Alliance:	Mpotm1Mae page

Germline Transmission:	Earliest citation of germline transmission: J:53993
Parent Cell Line:	BK4 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 6 and 7. Northern blot analysis on bone marrow RNA derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. Furthermore, neutrophils and monocytes of homozygous mutant mice were shown to completely lack enzyme activity. (J:53993)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mpo Mutation:	54 strains or lines available

Original:	J:53993 Aratani Y, et al., Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase. Infect Immun. 1999 Apr;67(4):1828-36
All:	20 reference(s)