Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(Ins2-cre)25Mgn
Name:	transgene insertion 25, Mark A Magnuson
MGI ID:	MGI:2176227
Synonyms:	Ins2cre, Ins-Cre, M line, RIP2-cre, RIP2Cre, Rip-cre, RIPCre, [RIP]-Cre, RIP Cre, RIP-Cre, TgN(ins2-Cre)25Mgn
Transgene:	Tg(Ins2-cre)25Mgn  Location: Chr7:62640905-62658305 bp  Genetic Position: Chr7, Syntenic
Alliance:	Tg(Ins2-cre)25Mgn page

Strain of Origin:

(C57BL/6 x DBA)F2

Transgene Type:    Transgenic (Recombinase) Mutations:    Duplication, Insertion   Tg(Ins2-cre)25Mgn expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note rat Ins2 (24506) Ins2  (MGI:96573)   Mutation details: This transgene expresses Cre recombinase with a human growth hormone polyadenylation signal under the control of the rat insulin promoter (Ins2), which is active in pancreatic beta cells and in neurons of the hypothalamus. 9 copies of the transgene are estimated to be present. Transgene insertion occurred on Chr 7, causing a 17400 bp duplication. (J:51826)

Activity:	Tissue activity of this recombinase allele
Driver:	Ins2 (rat) Summary of all recombinase alleles driven by Ins2. Comparative matrix view of recombinase activities Alliance rat Ins2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	104041 assay results 6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

List all tumor models in MMHCdb carrying Tg(Ins2-cre)25Mgn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:51826 Postic C, et al., Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem. 1999 Jan 1;274(1):305-15
All:	285 reference(s)