Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Pik3r2tm1Lca
Name:	phosphoinositide-3-kinase regulatory subunit 2; targeted mutation 1, Lewis C Cantley
MGI ID:	MGI:2159732
Synonyms:	p85beta-, Pik3r2-
Gene:	Pik3r2  Location: Chr8:71220820-71229357 bp, - strand  Genetic Position: Chr8, 34.15 cM
Alliance:	Pik3r2tm1Lca page

Germline Transmission:	Earliest citation of germline transmission: J:73703
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting construct was designed to replace the 5' UTR, start codon and first exon with a PGK-neo cassette. (J:97576)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

List all tumor models in MMHCdb carrying Pik3r2tm1Lca

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pik3r2 Mutation:	38 strains or lines available

Original:	J:73703 Ueki K, et al., Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):419-24
All:	28 reference(s)