Aifm1<tm1Pngr> Targeted Allele Detail MGI Mouse (MGI:2159372)

Aifm1^tm1Pngr
Targeted Allele Detail

Summary

Symbol:	Aifm1^tm1Pngr
Name:	apoptosis-inducing factor, mitochondrion-associated 1; targeted mutation 1, Josef M Penninger
MGI ID:	MGI:2159372
Synonyms:	aif^-
Gene:	Aifm1 Location: ChrX:47563821-47602440 bp, - strand Genetic Position: ChrX, 25.68 cM, cytoband A6

Mutation
origin

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exon 3. Northern and western blotting confirmed that no transcript or protein was expressed from this allele (data not shown). (J:68434)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Aifm1 Mutation:	10 strains or lines available

Notes

Cells fail to establish chimeric mice in a rag1 null or C57BL/6 background; however, ES cells can differentiate into all three germ layers. J:68434

References

Original:	J:68434 Joza N, et al., Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 2001 Mar 29;410(6828):549-54
All:	1 reference(s)

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