Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Fkbp1atm1Zuk
Name:	FK506 binding protein 1a; targeted mutation 1, Martin M Matzuk
MGI ID:	MGI:2158807
Synonyms:	FKBP12m1
Gene:	Fkbp1a  Location: Chr2:151384403-151403611 bp, + strand  Genetic Position: Chr2, 74.83 cM
Alliance:	Fkbp1atm1Zuk page

Germline Transmission:	Earliest citation of germline transmission: J:45536
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An Hprt minigene replaced a genomic fragment containing exons 3 and 4, which encode domains required for protein activity. (J:45536)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

16 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fkbp1a Mutation:	14 strains or lines available

Original:	J:45536 Shou W, et al., Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12. Nature. 1998 Jan 29;391(6666):489-92
All:	5 reference(s)