Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Chrna9tm1Bedv
Name:	cholinergic receptor, nicotinic, alpha polypeptide 9; targeted mutation 1, Belen Elgoyhen and Douglas E Vetter
MGI ID:	MGI:2158742
Synonyms:	alpha9-, alpha9 knockout, Chrna9tm1Jbdv
Gene:	Chrna9  Location: Chr5:66092264-66134669 bp, + strand  Genetic Position: Chr5, 33.84 cM
Alliance:	Chrna9tm1Bedv page

Germline Transmission:	Earliest citation of germline transmission: J:55406
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 4 and flanking intronic sequences were replaced with a neomycin selection cassette. The deleted sequences encode the ligand-binding site and the first two transmembrane domains. RT-PCR analysis on nasal epithelium derived from homozygous mice confirmed that no detectable transcript containg sequences from exon 4 is produced from this allele. (J:55406)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chrna9 Mutation:	39 strains or lines available

Original:	J:55406 Vetter DE, et al., Role of alpha9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation. Neuron. 1999 May;23(1):93-103
All:	30 reference(s)