Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tgfb3tm1Jhg
Name:	transforming growth factor, beta 3; targeted mutation 1, John H Groffen
MGI ID:	MGI:2158731
Synonyms:	TGF-beta3-
Gene:	Tgfb3  Location: Chr12:86103519-86125815 bp, - strand  Genetic Position: Chr12, 40.09 cM
Alliance:	Tgfb3tm1Jhg page

Germline Transmission:	Earliest citation of germline transmission: J:29902
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin selection cassette was inserted into exon 6. RT-PCR analysis on total head RNA of newborn homozygous pups demonstrated that no detectable transcript is produced from this allele. (J:29902)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tgfb3 Mutation:	34 strains or lines available

Original:	J:29902 Kaartinen V, et al., Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction. Nat Genet. 1995 Dec;11(4):415-21
All:	9 reference(s)