Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Npy1rtm1Mnak
Name:	neuropeptide Y receptor Y1; targeted mutation 1, Motonao Nakamura
MGI ID:	MGI:2158702
Gene:	Npy1r  Location: Chr8:67149844-67159444 bp, + strand  Genetic Position: Chr8, 33.15 cM, cytoband B3-C2
Alliance:	Npy1rtm1Mnak page

Germline Transmission:	Earliest citation of germline transmission: J:51684
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exons 2 and 3 are replaced with a neomycin resistance cassette. Northern blot analysis from brain confirmed the absence of transcript in homozygous mutant animals. The Y5 receptor, which resides in close proximity to the Y1 receptor, was unaffected by the gene targeting, as demonstrated by Northern analysis. (J:51684)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npy1r Mutation:	25 strains or lines available

Original:	J:51684 Kushi A, et al., Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15659-64
All:	1 reference(s)