Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Men1tm1.1Ctre
Name:	multiple endocrine neoplasia 1; targeted mutation 1.1, Judy S Crabtree
MGI ID:	MGI:2158698
Synonyms:	dN3-8, Men1-, Men1deltaN3-8, Men1deltaN3-8
Gene:	Men1  Location: Chr19:6385009-6390921 bp, + strand  Genetic Position: Chr19, 4.45 cM, cytoband A
Alliance:	Men1tm1.1Ctre page

Germline Transmission:	Earliest citation of germline transmission: J:67128
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: This allele is a derivative of Men1tm1Ctre in which the neomycin cassette and exons 3-8 of the gene were removed by Cre mediated recombination by crossing mice carrying the Mentm1Ctre allele to mice expressing Cre recombinase under the control of a ubiquitous promoter. (J:67128)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

List all tumor models in MMHCdb carrying Men1tm1.1Ctre

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Men1 Mutation:	40 strains or lines available

Original:	J:67128 Crabtree JS, et al., A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1118-23
All:	19 reference(s)