Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Camk4tm1Arm
Name:	calcium/calmodulin-dependent protein kinase IV; targeted mutation 1, Anthony R Means
MGI ID:	MGI:2158694
Gene:	Camk4  Location: Chr18:33067984-33324281 bp, + strand  Genetic Position: Chr18, 18.15 cM
Alliance:	Camk4tm1Arm page

Germline Transmission:	Earliest citation of germline transmission: J:70570
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing the first two exons was replaced with a neomycin selection cassette. Western blot analysis on brain extracts derived from homozygous mice demonstrated that no detectable protein is produced from this allele. (J:70570)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Camk4 Mutation:	37 strains or lines available

Original:	J:70570 Wu JY, et al., Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4. Nat Genet. 2000 Aug;25(4):448-52
All:	11 reference(s)