Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bidtm1Sjk
Name:	BH3 interacting domain death agonist; targeted mutation 1, Stanley J Korsmeyer
MGI ID:	MGI:2158671
Synonyms:	Bid-
Gene:	Bid  Location: Chr6:120870080-120894074 bp, - strand  Genetic Position: Chr6, 57.02 cM
Alliance:	Bidtm1Sjk page

Germline Transmission:	Earliest citation of germline transmission: J:57073
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 4.2 kb genomic fragment containing exons 1, 2 and part of 3 was replaced with a neomycin selection cassette inserted in reverse transcriptional orientation to the gene. The deleted sequences encode the BH3 domain of the protein. Western blot analysis on spleen and thymus samples derived from homozygous mice demonstrated that no detectable protein is produced from this allele. (J:57073)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bid Mutation:	44 strains or lines available

Original:	J:57073 Yin XM, et al., Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature. 1999 Aug 26;400(6747):886-91
All:	74 reference(s)