Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | Notes | References

Symbol: Ptgs2tm1Unc Name: prostaglandin-endoperoxide synthase 2; targeted mutation 1, University of North Carolina MGI ID: MGI:2158457 Synonyms: Cox2-, COX-2-, PGHS-2-, Ptgs2tm1Smi Gene: Ptgs2  Location: Chr1:149975851-149983978 bp, + strand  Genetic Position: Chr1, 63.84 cM, cytoband H1 Alliance: Ptgs2tm1Unc page

Hypertoprhy of glomeruli in Ptgs2tm1Unc/Ptgs2tm1Unc mice that is not seen in Ptgs2tm1.1Wls/Ptgs2tm1.1Wls mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:29510
Parent Cell Line:	BK4 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette was inserted into exon 8. A 104 bp DNA fragment containing sequences encoding essential residues tyrosine 371 and histidine 374 was also deleted. Northern blot analysis on mRNA derived from LPS-induced macrophages from homozygous mice demonstrated that an aberrant 6.0 kb transcript is produced from this allele. However, western blot analysis confirmed that no detectable protein is produced from this allele in LPS-induced macrophages derived from homozygous mice. (J:29510)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

29 anatomical structure(s)

List all tumor models in MMHCdb carrying Ptgs2tm1Unc

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptgs2 Mutation:	72 strains or lines available

Original:	J:29510 Morham SG, et al., Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell. 1995 Nov 3;83(3):473-82
All:	141 reference(s)