Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bcl6tm1Sdt
Name:	B cell leukemia/lymphoma 6; targeted mutation 1, Louis M Staudt
MGI ID:	MGI:2158439
Synonyms:	BCL-6-
Gene:	Bcl6  Location: Chr16:23783802-23807602 bp, - strand  Genetic Position: Chr16, 15.26 cM
Alliance:	Bcl6tm1Sdt page

Germline Transmission:	Earliest citation of germline transmission: J:39815
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing coding sequences for the zinc finger DNA binding domain was replaced with a neomycin selection cassette. Western blot analysis on spleen cells derived from homozygous mice demonstrated that no detectable protein was produced from this allele. (J:39815)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcl6 Mutation:	55 strains or lines available

Original:	J:39815 Dent AL, et al., Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science. 1997 Apr 25;276(5312):589-92
All:	26 reference(s)