Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Bcl6tm2Rdf
Name:	B cell leukemia/lymphoma 6; targeted mutation 2, Riccardo Dalla-Favera
MGI ID:	MGI:2158438
Synonyms:	BCL-6-
Gene:	Bcl6  Location: Chr16:23783802-23807602 bp, - strand  Genetic Position: Chr16, 15.26 cM
Alliance:	Bcl6tm2Rdf page

Germline Transmission:	Earliest citation of germline transmission: J:40769
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing exons 4 through part of exon 10 was replaced with a neomycin selection cassette. Nearly all of the coding sequences were deleted in this allele. (J:40769)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

10 anatomical structure(s)

List all tumor models in MMHCdb carrying Bcl6tm2Rdf

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl6 Mutation:	55 strains or lines available

Original:	J:40769 Ye BH, et al., The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet. 1997 Jun;16(2):161-70
All:	16 reference(s)